About Omega-3s and Omega-6s

This week I’d like to share some of the things I’ve learned about two particular polyunsaturated fatty acids, omega-3 and omega-6 fatty acids. 

Let’s start with omega-3 fatty acids. These are compounds in the form of a long chain of carbon molecules with several double bonds, each of which acts as a pivot point. Flexible pivot points confer the ability to move in many directions, essential for movement and flexibility. Omega-3s owe their flexibility to all those double bonds, the last of which is located just three carbons from the tail, or omega, end of the molecule. That’s why it’s called an omega-3 fatty acid. Omega means end. In contrast, omega-6 fatty acids contain fewer double bonds, and the last one is located six carbons from the tail. Hence, omega-6. 

Among many other essential functions, omega-3’s play a vital role in photosynthesis, whereby green leaves convert sunlight to plant food. This is why green leaves are an important source of omega-3s.

Omega-3 fatty acids are found in all green plants (another reason to eat your vegetables). The largest mass of greens on Earth is phytoplankton, tiny sea plants that are eaten by little fish, which are then eaten by bigger fish, and so on. Sea creatures eat literally tons of phytoplankton, in part because fish must take in at least one full percent of their calories as omega-3s in order to keep their blood liquid and survive in cold water environments. Warm-blooded animals, on the other hand, need only half that. This is why fish, fish oil, and algae are such good sources of omega-3s.

In biological systems, two significant omega-3 fatty acids are called DHA and EPA. EPA is a blood thinner with anti-inflammatory properties. DHA is incorporated into cell membranes to keep them flexible and functional. DHA is like a “quick-change artist” with hundreds of possible configurations. According to Susan Allport*, “DHA creates membranes with…behavior that is almost liquid-like.” Cell membranes aren’t inert like dry wall. They live and breathe, and they function to keep the cell’s internal environment completely separate from the outside environment.

DHA has other important functions. It makes up 25 percent of brain tissue. It reduces the likelihood of heart arrhythmias, or abnormal rhythms. It helps the eye to see better by increasing the amount of rhodopsin, a light-responsive protein in the retina’s rods. DHA also appears to improve insulin sensitivity, meaning that it lowers the risk of diabetes and obesity.

Omega-3s do, however, have one important limitation: All those double bonds react easily with oxygen, which makes them, chemically speaking, unstable. In fact, oxidation is the major cause of food rancidity. This reactivity makes omega-3s an unreliable way to store fat in nature.

And that is where omega-6s enter the picture.

Omega-6s, less reactive because they have fewer double bonds, are a much better choice for a different job — storage. This is why omega-6s are the main fat in grains and seeds. Where long-term storage is all-important, the stability of omega-6s makes them the preferred form in which to store fat. Plants store fat as omega-6s until seeds germinate and initiate photosynthesis. Then they release an enzyme that converts omega-6s to omega-3s. Plants are able to convert omega-6s into omega-3s whenever they need.

With the exception of lions, most animals and humans do not have this enzyme, so once an omega-6, always an omega-6. And if you eat a diet high in omega-6s, your cell membranes will not be as flexible as if you ate sufficient omega-3 fatty acids.

The stable chemical configuration of omega-6s increases shelf life considerably, which makes them the leading fatty acid of choice for ultraprocessed food products, including vegetable oils. It explains why it is not coincidental that the ratio of omega-6s to omega-3s in our diet has climbed from approximately 1:1 throughout history to upwards of 50:1 or higher today. People living on fast food and doughnuts may be eating 50 times as much omega-6s as omega-3s. That’s a problem.

Don’t think of omega-3s as good for you and omega-6s as bad. It’s not about good and bad. It’s about being in a balanced ratio. Omega-6 fatty acids in plants serve as a stable, reliable system for storing fat until the plant needs omega-3s. Omega-3s are flexible, and omega-6s are stiff. Omega-3s are reactive, whereas omega-6s are stable. We need both to function optimally.

Omega-6s, with fewer double bonds, are more stable and, therefore, less prone to oxidation and breakdown, which is why omega-6s are found in highest concentration in grains and seeds. Dry beans may remain viable for centuries under certain circumstances. That is obviously not true of lettuce, under any circumstances.

Stiff membranes may be good for seeds and grains, but they are a tremendous liability for green leaves, not to mention brains, blood vessels, eyes, and joints. High blood pressure, inflammatory diseases, and insulin resistance are predictable consequences of stiff cell membranes.

*Author of The Queen of Fats: Why Omega-3s were Removed from the Western Diet and What We Can Do to Replace Them


The Skinny on Fat

With all the talk about saturated fat and monounsaturated fat, polyunsaturated fat and trans fat, it’s easy to get confused about how they fit into the big picture, and to understand what it means for the food choices you make. I’d like to give you another strategy for figuring out what to eat. Instead of FAT, I am going to talk about FATTY ACIDS. First, some definitions.

If fat is a sentence, then fatty acids are words. If fat is a word, then fatty acids are letters. If fat is the universe, then fatty acids are galaxies. If fat is a solar system, fatty acids are planets and moons. If fat is a pyramid, fatty acids are bricks. 

If foods are words, then I want to focus on the letters. Today, I want to talk not about olives and avocados, not olive oil and avocado oil, but rather about the o’s and the e’s with which they are spelled. This conversation is not about lard or chicken fat. It’s about the fatty acids of which they are composed. Continue reading


The Importance of Avocados, Olive Oil, and Peanut Butter

Today I’m talking about fats, one of the macronutrients. Protein, fat, and carbohydrate are the three major macronutrients in the diet. Water is sometimes included as a fourth macronutrient.

But first, I’d like to begin with a few words on carbs: The term carbohydrates refers to carbohydrate that comes from a plant that grows in the soil. Whether leaf or fruit or root or stem, this kind of carbohydrate is always, always rich in fiber and phytonutrients. Except for milk and honey, carbohydrate doesn’t really exist in nature without the fiber. This means that whenever you come across carbohydrate without fiber attached, humans probably made it that way. But we don’t call whole, or fiber-rich, carbohydrates “healthy carbohydrates.” In a blog about good health and nutrition, you can assume that I’m always talking about the healthy kind. And while it is true that we, as a society, are drowning in stripped, “unhealthy,” carbs, people do not feel the need to keep reminding themselves.  Continue reading


A Primer on Dietary Fat

A great many parts of our bodies rely on fat to perform their essential functions, and I’d like to review some of them here. The better you understand fats, their functions, and their structures, the less susceptible you will be to the advertising that influences consumers to purchase products made with industrially-modified fats. Today we’re talking about fat. For purposes of this essay, consider the terms “fat” and “oil” to be interchangeable.  Continue reading


The Esselstyns & Plant-Based Eating

Going on ten years ago now, I had the pleasure of seeing Dr. Caldwell and Anne Esselstyn present on plant-based eating. The plant-based diet, which they began many decades ago, means eating only those items that belong to the category of “intact” carbohydrates, i.e., carbs with an intact fiber matrix. The plant-based diet is similar to the vegan diet, with several exceptions as enumerated below. Continue reading


Nourishing Fats for Healthy People

Today I’m talking about the word “fat,” and the term “healthy fats.” Fats are one of the three macronutrients: protein, fat, and carbohydrate.

A brief aside about carbs: The term carbohydrates included in the list of macronutrients refers to carbohydrate that comes from a plant that grows in the soil. Whether leaf or fruit or root or stem, this kind of carbohydrate is always, always rich in fiber and phytonutrients. Except for milk and honey, carbohydrate doesn’t really exist in nature without the fiber. Continue reading


Giving Your Body the Help it Needs

Some years ago, when my patient, Mrs. Price, heard me say that her blood sugar measurement had come back from the lab at 204, a single tear ran down her cheek as she said,  “My eldest granddaughter is getting married next year.” A blood sugar measurement over 200 is one way to confirm a diagnosis of diabetes. Both of Mrs. Price’s parents had died in their 60’s from complications of uncontrolled diabetes, or chronically elevated high blood sugars. This is what I told her. Continue reading


And the Winner is Real Food

Years ago, the article Can We Say What Diet is Best for Health?, by David Katz and Stephanie Meller from Yale University School of Public Health, was published in the Annual Review of Public Health. A related essay by James Hamblin, Science Compared Every Diet, and the Winner is Real Food, was subsequently published in the Atlantic.  

Katz and Meller compared low-carb, low-fat, low-glycemic, Mediterranean, DASH, Paleolithic, and vegan diets, concluding that “A diet of minimally processed foods close to nature, predominantly plants, is decisively associated with health promotion and disease prevention.”  Michael Pollan said, “Eat food. Mostly plants. Not too much.” More recent research continues to confirm these findings. Continue reading



YOUR HEALTHY PLATE: Judith’s Avocado-Chickpea Dip

My friend Judith, a number of whose remarkable, inspired recipes have appeared in these pages, has brought us yet another! She calls this one her “newest obsession.” It comes to her from a beloved family member who made it for her on the occasion of a recent visit. She described it to me over breakfast last week, and I could practically taste it as her words came rolling across the table —  Continue reading